| abstract |
An isolated paramyxovirus, a morbillivirus (FmoPV), isolated nucleic acids encoding the genome of FmoPV, isolated amino acid sequences of FmoPV protein, antibodies to FmoPV and its proteins, and uses thereof are provided. In certain embodiments, the modified FmoPV is a feline morbillivirus. A recombinant FmoPV comprising a modified FmoPV gene or gene segments and the use of such virus are provided. The recombinant FmoPV may be used in the prevention and/or treatment of diseases related to FmoPV or as a delivery vector. A diagnostic assay for the FmoPV is provided. In certain embodiments, the FmoPV causes kidney disease. In certain embodiments, the kidney disease is in felines. In certain embodiments, the kidney disease is tubulo interstitial nephritis ("TIN"). A quantitative assay for the detection of the FmoPV, natural or artificial variants, analogs, or derivatives thereof is provided. In certain embodiments, the quantitative assay is reverse transcription and polymerase chain reaction (RT-PCR). A vaccine and a kit containing the vaccine for the prevention and treatment of FmoPV infection are provided. A diagnosis kit that comprises nucleic acid molecules for the detection of the FmoPV is also provided. |