| abstract |
The present invention is related to a nucleic acid molecule capable of binding to CGRP, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5 ' HWn 1 n 2 YGGAn 3 An 4 UMn 5 n 6 Yn 7 n 8 n 9 n 10 n 11 Kn 12 Rn 13 ADn 14 n 15 ARn 16 Un 17 Cn 18 n 19 Un 20 n 21 3 ' [SEQ ID NO: 99], wherein H, W, Y, G, A, U, M, B, K, R, D, C are ribonucleotides, and n 1 is R or dG, n 2 is U or dT, n 3 is K or dG, n 4 is C or dC, n 5 is M or dC, n 6 is B or dU, n 7 is N or dG, n 8 is Y or dT, n 9 is N or dC, n 10 is R or dG, n 11 is V or dA, n 12 is K or dT or dU, n 13 is G or dG, n 14 is A or dA, n 15 is U or dT, n 16 is R or dG, n 17 is Y or dC, n 18 is C or dC, n 19 is B or dC, n 20 is C or dC, n 21 is C or dC, and dG, dT, dC, dA and dU are 2'-deoxyribonucleotides. |