| abstract |
The synthetic peptides have the sequence: [RrA\ A 2 , A 6 , A 8, A 11 , A 12 , A 15 , A 20 , A 21 , A 22 , Nle 27 , A 28 , A 29 , A30]hGH-RH(1 -30)-R 2 (SEQ ID NO: 1 ) wherein R 1 is Ac, Tfa, or is absent, A 1 is Tyr, Dat, or N-Me-Tyr, A 2 is Ala, D-Ala, Abu, or D-Abu, A 6 is Phe or Fpa5, A 8 is Asn, Ala, Gin, Thr, or N-Me-Ala, A 11 is Arg, His, or Har, A 12 is Orn, or Lys(Me)2, A 15 is Abu or Ala A 20 is Arg, His, or Har, A 21 is Orn, or Lys(Me)2, A 22 is Leu, or Orn, A 28 is Ser, or Asp, A 29 is Arg, Har, Agm, D-Arg, or D-Har, A 30 is Arg, Agm, Ada, Amc, Aha, Apa, Har, D-Arg, D-Har, Gab, Gin, D-GIn, Gin-Gab, D-Gln-Gab, or is absent, R 2 is -NH 2 , -OH, -NHR 2 , -N(R 2 ) 2 , or -OR 2 , in which R 2 is any of C 1-12 alkyl, C 2-12 alkenyl, or C 2-12 alkinyl, provided that if A 29 is Agm then A 30 and R 2 are absent A 1 is N-Me-Tyr only, and pharmaceutically acceptable salts thereof. |