http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013082207-A1

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publicationDate 2013-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2013082207-A1
titleOfInvention T2 spectral analysis for myelin water imaging
abstract Apparatus, methods, and other embodiments associated with the spectral analysis of T 2 spectral data are described. One example magnetic resonance imaging (MRI) method includes accessing a data set comprising T 2 spectral data associated with a magnetic resonance imaging (MRI) signal received from an object. The T 2 spectral data is decomposed with multi-exponential functions to determine T 2 spectra. The T 2 spectral amplitude is regularized with a regularized constant. The regularized constant is sufficiently large to smooth the T 2 spectra so adjacent pixels of the T 2 spectral data have similar characteristics. The T 2 spectral data is weighted so that the regularization is uniformly weighted for the spectral amplitudes. The T 2 spectra is partitioned into intervals corresponding to myelin water fraction (MWF), tissue water fraction (TWF), Long T 2 water fraction (LWF), and cerebrospinal fluid fraction (CSF). Parametric maps are generated based, at least in part, on the T 2 spectral data.
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