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publicationDate 2013-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2013071411-A8
titleOfInvention Methods for the synthesis of 13c labeled dha and use as a reference standard
abstract A method for preparing 13 C labeled docosahexaenoic acid (DHA) represented by Formula A: The method comprises the conversion of 2-pentyn-l-ol to 13 C labeled DHA by reaction with propargyl alcohol, 13 C labeled propargyl alcohol and methyl pent-4-ynoate. The various steps involved include tosylation, coupling, bromination, selective hydrogenation and ester hydrolysis to obtain the final product.
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