| abstract |
The present invention provides a method of determining the risk of developing metastasis and/or tumor relapse in a colorectal cancer patient, comprising the steps of providing a biological sample of said colorectal cancer patient, and determining in said biological sample the methylation status and/or the expression level of a gene selected from the group consisting of LGR5, APCDD1, ΑΧIΝ2, DKK1, and ASCL2, and determining an increased risk of developing metastasis and/or tumor relapse, under the condition that hypermethylation and/or under expression is determined in a gene selected from the group consisting of LGR5, APCDD1, ΑΧΓΝ2, DKK1, and ASCL2. |