Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e2285edbbe70ae81838245ae616e11d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3507074ab5d169ae97a1529a1736c369 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1763896613178524211bd0e92d69e6f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78587acbfc8d4c9e9ac3baa7021087d7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y102-01036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16134 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-21 |
filingDate |
2012-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf56e029ae07392a9a8e08374249b1cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7840c5e357aba822289890a0f2e6a833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f503f53bad91681b62bc2d524d54d72 |
publicationDate |
2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2013059442-A3 |
titleOfInvention |
Inhibition of retinoic acid production for hiv vaccination |
abstract |
A method and vaccine composition compressing a siRNA and/or a shRNA that targets a retinoic acid producing enzyme and an antigen. Silencing retinoic acid producing enzymes downregulates α4β7 expression on activated T and B cells. Immunization with a retinoic acid silencing mechanism greatly enhanced anti-HIV gp140 immune responses in the vaginal tract and periphery but not in the intestine, providing a unique strategy to redistribute anti-HIV mucosal immune responses on the front line of defense against HIV-1 with concomitant suppression of α4β7high CD4+ T cells. |
priorityDate |
2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |