abstract |
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y 1 is phenylene or heteroarylene; L 1 is a linker; Y 2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z 1 is C(0)OR 9 , C(O)NR 10 R 11 , C(0)R 11 , NR 10 C(O)R 11 , etc. |