| abstract |
The present invention provides methods for detecting or measuring the expression and/or activation levels of one or a plurality of signaling proteins in samples obtained from patients in a specific, multiplex, high-throughput assay. By detecting any alterations (e.g., dysregulated expression and/or activation) in one or more signaling proteins of interest, the present invention is particularly advantageous for aiding the prediction, diagnosis, prognosis, and/or monitoring of a pre-disease state (e.g., pre-metabolic syndrome such as pre-diabetes), a cancer, and/or a metabolic disorder (e.g., diabetes such as type 1 or type 2 diabetes). |