http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013054123-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42f077788667aab5c38c442fb6aeb1f0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 |
| filingDate | 2012-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5c064cb91282514f7659df15ee71a2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46a7f793db8a58104463ac4c7ec0bc16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc8420fe11e90a7056763702a03a9f7e |
| publicationDate | 2013-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2013054123-A1 |
| titleOfInvention | Methods |
| abstract | A method for promoting entry of an agent (introduced agent) into a cell, the method comprising the step of complexing the introduced agent in the presence of an entry- promoting agent and then exposing to cells, wherein the entry-promoting agent comprises a linear and/or branched or cyclic polymonoguanide/polyguanidine, polybiguanide, analogue or derivative thereof according to the following Formula 1a &b. The method also provides a means for formation of nanoparticles formed between the entry promoting agent and the introduced agent. wherein: "n", refers to number of repeating units in the polymer, and n can vary from 2 to 1000, for example from 2 or 5 to 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 150, 200, 250, 300, 350, 400, 450, 500, 600, 700, 800 or 900; G 1 and G 2 independently represent a cationic group comprising biguanide or guanidine, wherein L 1 , and L 2 are directly joined to a Nitrogen atom of the guanide; L 1 and L 2 are linking groups between the G 1 and G 2 cationic groups in the polymer and independently represent an aliphatic group containing C 1 -C 40 carbon atoms, for example an alkyl group such as methylene, ethylene, propylene, C 4 , C 5 , C 6 , C 7 , C 8 , C 9 or C 10 ; C 1 -C 10 , -C 20 , - C 30 , -C 40 , -C 50 -C 60 -C 70 , -C 80 , -C 9 0, -C- 100 , -C 110 , -C 120 , -C 130 or -C 140 , alkyl; or a C 1 -C 140 (for example C 1 , C 2 ,C 3 , C 4 , C 5 , C 6 , C 7 , C 8 , C 9 or C 10 ; C 1 -C 10 , -C 20 , -C 30 , -C 40 , -C 50 -C 60 , -C 70 , -C 80 , - C 90 , -C 100 , -C 11 0, -C 120 , -C 130 o or -C 140 ), cycloaliphatic, heterocyclic, aromatic, aryl, alkylaryl, arylalkyl, or oxyalkylene radical; or a polyalkylene radical optionally interrupted by one or more, preferably one, oxygen, nitrogen or sulphur atoms, functional groups or saturated or unsaturated cyclic moiety; N and G 3 are optional end groups; X can be either present or absent; L 3 , L 4 and X are linking groups between the G4 and G5 cationic groups in the polymer and independently represent an aliphatic group containing C 1 -C 140 carbon atoms, for example an alkyl group such as methylene, ethylene, propylene, C 4 , C 5 , C 6 , C 7 , C 8 , C 9 or C 10 ; C 1 -C 10 , -C 20 , -C 30 , - C 40 , -C 50 -C 60 , -C 70 , -C 80 , -C 90 , -C 100 , -C 110 , -C 120 , -C 130 or -C 140 , alkyl; or L 3 and L 4 and X can independently be C 1 -C 140 (for example C 1 ,C 2 , C 3 , C 4 , C 5 , C 6 , C 7 , C 8 , C 9 or C 10 ; C 1 -C 10 , -C 20 , -C 30 , -C 40 , -C 50 -C 60 , -C 70 , -C 80 , -C 90 , -C 100 , -C 110 , -C 120 , -C 130 or -C 140 ), cycloaliphatic, heterocyclic, aromatic, aryl, alkylaryl, arylalkyl, oxyalkylene radicals; or a polyalkylene radical optionally interrupted by one or more, preferably one, oxygen, nitrogen or sulphur atoms, functional groups as well as saturated or unsaturated cyclic moiety; "G 4 " and "G 5 " are cationic moieties and can be same or different, and at least one of them is a biguanidine moiety or carbamoylguanidine, and the other moiety may be biguanidine or carbamoylguanidine or amine; and cationic moieties G 4 and G 5 do not contain single guanidine groups. The entry-promoting agent may comprise homogeneous or heterogeneous mixture of one or more of agents arising from formulae 1 a and b, for example polyhexamethylene biguanide (PHMB), polyhexamethylene monoguanide (PHMG), polyethylene biguanide (PEB), polytetramethylene biguanide (PTMB), polyethylene hexamethylene biguanide (PEHMB), polymethylene biguanides (PMB), poly(allylbiguanidnio-co-allylamine), poly(N- vinylbiguanide), polyallybiguanide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3854380-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11044912-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10709119-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10136621-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9999208-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3068216-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016536271-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3049056-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2741645-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017037462-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018515116-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019373895-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016187198-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017141204-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017037462-A3 |
| priorityDate | 2011-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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