http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013050553-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a518e998cc6a69ab44d1cf18b25af8df |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 2012-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb16c72bf82759066742bf6984c6c74f |
| publicationDate | 2013-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2013050553-A1 |
| titleOfInvention | Process for the production of estetrol |
| abstract | The present invention relates to a process for the preparation of a compound of formula (I), hydrates or solvates thereof; (I) said process comprising the steps of a) reacting a compound of formula (II), with an acylating or a silylating agent to produce a compound of formula (III), (II) (III) wherein P 1 is a protecting group selected from R 1 CO-, or R 2 Si(R 3 )(R 4 )-, P 2 is a protecting group selected from (R 6 R 5 R 7 )C-CO-, or (R 2 )Si(R 3 )(R 4 )-, wherein R 1 is a group selected from C 1-6 alkyl or C 3-6 cycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C 1-4 alkyl; R 2 , R 3 and R 4 are each independently a group selected from C 1-6 alkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C 1-4 alkyl; R 5 is a group selected from C 1-6 alkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C 1-4 alkyl; R 6 and R 7 are each independently hydrogen or a group selected from C 1-6 alkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C 1-4 alkyl; b) reacting the compound of formula (III) in the presence of at least one oxidizing agent selected from permanganate salt, osmium oxide, hydrogen peroxide, or iodine and silver acetate to produce compound of formula (IV); and (IV)5 c) deprotecting the compound of formula (IV) to produce compound of formula (I). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-201900017414-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-202100019631-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023051937-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-3101348-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633406-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023001866-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023021026-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021044302-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-201900021879-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9988417-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-112020004564-T5 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016531159-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013034780-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10888518-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021058716-A1 |
| priorityDate | 2011-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 239.