| abstract |
The present invention provides (1) a production method for a non-human animal having a humanized liver, said method comprising transplanting human liver stem cells and/or liver precursor cells and/or immature liver cells to a non-human animal having liver damage, and inducing liver cell variation, (2) a non-human animal having a humanized liver produced using said method, (3) a method using said animal to investigate the pharmacokinetics and/or hepatotoxicity of a substance to be tested, (4) a production method for human liver cells, said method comprising transplanting human liver stem cells and/or liver precursor cells and/or immature liver cells to a non-human animal having liver damage, and inducing liver cell variation, and (5) a method using the human liver cells produced using said method to investigate the pharmacokinetics and/or hepatotoxicity of a substance to be tested. |