| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf2a3a767ae32dfcda1f4e6642aeadc9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-44 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate |
2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d06e575a2a7be5a31efefaddc533678a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_920c17621fdee48dc03000a99838ee1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63f692c12a9dc53175b36af0636e60a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d78b327983e66b5145843b69c3f5370 |
| publicationDate |
2013-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013041223-A1 |
| titleOfInvention |
Crystal structure of the 60s eukaryotic ribosomal subunit and its uses |
| abstract |
The present invention is directed to a crystal of the eukaryotic 60S ribosomal subunit of Tetrahymena thermophila in complex with the eukaryotic initiation factor 6 (elF6) of Tetrahymena thermophila , optionally together with a ligand, preferably an antibiotic such as cycloheximide; a method of producing said crystal and a composition comprising said crystal. In addition, the present invention relates to a computer system and a machine- readable medium comprising the atomic coordinates of the Tetrahymena thermophila 60S ribosomal subunit or coordinates derived therefrom as well as the use of said atomic coordinates for designing and selecting ligands that inhibit or modulate protein synthesis in eukaryotes. Also, the invention provides a method for identifying a potential ligand, preferably an inhibitor or modulator of a eukaryotic 60S ribosomal subunit. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106951617-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106951617-A |
| priorityDate |
2011-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |