| abstract |
The invention relates to the use of a compound of the following formula (I), for triggering the differentiation of mammalian cells from cardiomyocyte-like cells, the X being, independently, -NR 4 - or -O-, R 4 being hydrogen or C 1-6 -alkyl; R 1 being hydroxy, C 1-6 -alkyl, C 1-6 -alkoxy, carboxy, C 1-6 -alkoxycarbonyl, halogen, cyano, nitro, formyl, amino, C-i-6-alkylamino or Di-C 1-6 -alkylamino which, if necessary, are further substituted with one or more R 5 substituents selected from hydroxy, halogen, cyano and nitro; n equalling 0 to 5; R 2 being hydrogen, aryl, heteroaryl or C 1-6 -alkyl, an aryl- or heteroaryl group being further substituted, if necessary, with one or more R 6 substituents, the same options applying for R 6 as for R 1 , and one C 1-6 -alkyl group being further substituted, if necessary, with one or more R 5 substituents; R 3 being hydrogen, halogen, NR 4 R 7 , OR 7 , SR 7 or R 7 , and the same options applying for R 7 as for R 2 ; with the proviso that this compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid. |