| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fb1da8abe386d1ddb3637ec038c654b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15223624e90c58fb534d9dedf9bef399
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aec5265ccbec5bfca1fcb162666520c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e27c16508403279f403aae3ba45b4382 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2999-005 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43 |
| filingDate |
2012-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1a6dfe72f78eb370ea9709d1f69ec09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bac8f2860c1091108147bfa3221d1e50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a55bdc4bd941cd791e0eb3e55c8c119a |
| publicationDate |
2013-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013026021-A2 |
| titleOfInvention |
Trka as a target for inhibiting app cleavage and/or progression of alzheimer's disease |
| abstract |
In various embodiments method are provided for inhibiting (partially or fully) the C-terminal cleavage of APP resulting in the formation of APP-C31 peptide and APPneo (APP664) in a mammal. The methods typically involve administering or causing to be administered to the mammal a TrkA kinase inhibitor in an amount sufficient to reduce C-terminal cleavage of APP and production of a C31 peptide and/or APPneo. In certain embodiments the inhibitor comprises ADDN-1351 or a derivative thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10618974-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022130175-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022130171-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016134042-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022184130-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10800760-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018346450-A1 |
| priorityDate |
2011-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |