| abstract |
[Problem] To provide: an anti-human NGF antibody which is reduced in the influence on fetuses and the risk of adverse side effects including thrombosis while keeping a high neutralizing activity, and which has excellent safety, or an antigen-binding fragment thereof; and a means for preventing or treating various diseases for which human NGF is involved in the development of a disease state, which utilizes the antibody or an antigen-binding fragment thereof.n[Solution] An Fab' fragment of an anti-human NGF antibody, which comprises a heavy-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 6 and a light-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 4. |