| abstract |
As represented by Formula (I), a quinazoline derivative, or a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition having the compound or the pharmaceutically acceptable salt thereof or the solvate thereof, and a method for preparing the compound as represented by Formula (I). R 1 is represented by Formula (II) or Formula (III), and R 2 is represented by Formula (IV) or Formula (V), while the definitions of other substituent are as presented in the description. The compound represented by Formula (I) is provided with inhibitory activity with respect to one or several kinases among EGFR, VEGFR-2, c-erbB-4, c-met, tie-2, PDGFR, c-src, lck, Zap70, and fyn. |