| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36abe99efd34f0529766e9927084ffc5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec510cb0cf09015a1941381974f35f4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73f5f6f66fd1bcfbdf6161d5e2a7f609
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_459549086df37b5bed0003502de7e7aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db97f380bc33a2464116183bf8c5db23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f19593028a6ec10525194622d882a71f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2517ecdb190b0d37c23b1fe2af7ccbc6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C46-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C46-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D301-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C37-07 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-477
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-63 |
| filingDate |
2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdd9f5e1bc556cf8e143205442d20fa0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fe441c15b0829c74c8a267d4f3899c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72fbb46d7aed07a19718868a5d06ed29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40e4fc6e739f032091debfd53009d49e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4deca3c7c8a10ee118db6d872baf0ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d841015170646e2cacc9797f2dd97c47 |
| publicationDate |
2013-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013014486-A1 |
| titleOfInvention |
Improved synthesis of 2-(4-(4-chlorophenyl) cyclohex-1-enyl) -3, 4-dihydronaphthalen-1 (2h)-one; an intermediate for atovaquone |
| abstract |
A process for preparation of 2-(4-(4-chlorophenyl) cyclohex-l-enyl)-3,4-dihydronaphthalen- 1(2H)-one (V), key intermediate for synthesis of Atovaquone [I]. The process for preparation of compound(V) comprising of the steps of; i) Reaction of 2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)-3,4-dihydronaphthalen- 1(2H)-one (IV) with trifluro acetic anhydride in presence of base in organic solvent to yield compound of formula (XIa) ii) Elimination of trifluoroacetyl functionality of compound (XIa) in organic solvent and in presence of organic base to give compound of formula (V). The invention also provides a Process for preparation of compound(XIa) comprising of the steps of; i) reaction of 2-(4-(4-chlorophenyl)-l-hydroxy cyclohexyl)-3,4-dihydronaphthalen- 1(2H)-one (IV) with trifluro acetic anhydride in presence of organic base in organic solvent. A further process is provided for preparation of compound(V) from compound (XIa) comprising elimination reaction of trifluoroacetyl functionality compound (XIa) in organic solvent and in presence of organic base. |
| priorityDate |
2011-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |