http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013012628-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4e2926202600f2e01a5ef6e469f213a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_751562df05f1831baef905641425c407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a720c7e62a119bd050eebf87794f52b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b59cbf45fe8f47736fdbbe8f844c7b7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2012-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9fd06a01dd23cf494633e2d35c638a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9429dae7b7ae90a2f60ce7a251c04f6e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a6b31b837a747a929246fc2071a11eb |
| publicationDate | 2013-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2013012628-A3 |
| titleOfInvention | Immune-stimulating photoactive hybrid nanoparticles |
| abstract | Provides is a therapeutic technology that combines the phototoxic and immune- stimulating ability of photodynamic therapy with the widespread effectiveness of the immune system to reduce the viability of such as cancer cells and tumors. The nanoparticle compositions of the disclosure combine an immunostimulant with a photosensitizer using a nanoparticle delivery platform. For example, zinc pthalocyanine, which is a long-wavelength absorbing photosensitizer, integrated into a polymeric nanoparticle core made up of poly(D, L-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG). The outside surface of the core can be coated with metallic nanoparticles, which are then modified with CpG- ODN. Metastatic mouse breast carcinoma cells showed significant photocytotoxicity of the hybrid after irradiation with a 660 nm LASER light and this activity was remarkably better than either treatment alone. Treatment of mouse bone marrow derived dendritic cells with the photodynamic therapy-killed 4T1 cell lysate showed that the combination of photodynamic therapy with a synerg istic immunostimulant in a single nanoparticle system resulted in an immune response suitable for the treatment of such as a metastatic cancer. |
| priorityDate | 2011-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.