http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013011442-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61ede73755408800f4129fc308410911 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0f4f8190960626ec922a1f03bcd4aba http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b8c7545a4e4201bbe8957cae9956800 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3651d8efd36a8571d886a943ccb73f74 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate | 2012-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fa9a7eecf882123799b4008c84cd22b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40e58b2a93ccfb2dadbea890d3f71295 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55b674ee032721b1e2078f0bf765608a |
| publicationDate | 2013-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2013011442-A1 |
| titleOfInvention | Process for preparation of fondaparinux and its intermediates |
| abstract | The present invention relates to a process for the preparation of 3-O-benzyl- 1,2-O- isopropylidene-α-D-glucofuranuronic acid (Formula IV) and ester (Formula V) thereof. The process comprises benzylation of l,2:5,6-di-O-isopropylidene-α-D-glucofuranose (Formula I; hereinafter, referred to as diacetone-D-glucose) in the presence of tetrabutylammonium bromide, followed by selective hydrolysis of the product formed (Formula II) using sulfuric acid to obtain 3-O-benzyl- 1,2-O-isopropylidene-α-D- glucofuranose (Formula III). Compound of Formula III is then oxidized to compound of Formula IV which upon esterification provides corresponding ester of Formula V. The process of the invention can be used in the production of fondaparinux sodium, a heparin and blood clotting factor Xa inhibitor.(Formula I, II, III, IV, V) (I) (II) (III) (IV) (V) wherein R is optionally branched alkyl group. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107365335-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107365335-B |
| priorityDate | 2011-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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