| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7aa001f3235c07b0298867908d45e21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6bc55843e82eac46c6445ae8090e9bfc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb01caf7578e5d66ff398beaea2cf4d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0127633f47481136c248b2863d90b3a8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-765
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-347
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2440-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A90-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-198
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-145 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2012-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f05bd752ab309bdb19bc8a03b05c1f13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8f97a0fd8cd5a422561c58c82c1e1c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3841a742dedd975b5cac7034985a103 |
| publicationDate |
2013-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013010085-A2 |
| titleOfInvention |
Diagnosis, prognosis, and treatment of kidney disease |
| abstract |
The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4234039-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3355058-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2015419259-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017116465-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2927692-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11026873-B2 |
| priorityDate |
2011-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |