| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ae83c979b315fc6af45259d79446302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2e7bbaa07248dff447b39fee13fdcd6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_872cec0d4cc36ee6bc5b69fa7eba19d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_716e9a2606ffd4ba1a2a3917e4a402fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab82810ad3634768d8a0fcd91a333bfc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_156ebfe252b095700761b2c5bb795240 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1307
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-604
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-603
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-602
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate |
2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9a204b6f1c906d38dac37f5f9a31414
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a452dc137f0aa6355bdf677ef185f544
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d11bbe754565262847f08da7e552a3c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb76c7d419b5fee441254e152132cbae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fb608375feb7b3ca8de87f115c40561 |
| publicationDate |
2013-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013002419-A1 |
| titleOfInvention |
Mitochondrial disease-specific induced pluripotent stem cells, method of producing same and use thereof |
| abstract |
The present invention provides induced pluripotent stem (iPS) cells generated from a mitochondrial disease patient with a mutation in mitochondrial DNA, which exhibit a bimodal degree of mutation heteroplasmy, namely mutation-rich mitochondrial disease-specific iPS (Mt-iPS) cells which have increased mutation frequencies and mutation-free Mt-iPS cells in which the mutation frequencies decreased to undetectable levels. Also provided is a method of producing the mutation-rich and mutation-free Mt-iPS cells, as well as a use of the former as a source of model cells of mitochondrial diseases and a use of latter as a source of cells for autologous transplantation therapy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022101440-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111269883-A |
| priorityDate |
2011-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |