| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4603957edd217fd9363b2526f6bbebe2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_211915e881a9649d98dbd29252550fe3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_398bd82c62cbd132eb68b6f1b294c412
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3507074ab5d169ae97a1529a1736c369
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0438a6abf5c18ce4c1158795ab6d7982
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a1f3e261537e0327c35e6ebc6624466 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-16 |
| filingDate |
2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1368198e4a5f185c2f2a82743e215ca1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23034f9908938cfa16a020efe0e4925c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b504435a06d211b9ec5cbe0912fa7e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_480f61883d109ac1575519d374dd7c4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c84cec7100b54859d46d77908283c42f |
| publicationDate |
2013-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013000277-A1 |
| titleOfInvention |
Method for preparing broad-spectrum long-acting penicillin antibiotic ticarcillin disodium |
| abstract |
Provided is a method for preparing ticarcillin disodium with less side reaction and strong controllability in mild reaction condition using fewer steps, which comprises (1) reacting 3-thiophene malonic acid with N-hydroxyl succinimide in an organic solvent and under catalysis of DCC and DMAP to obtain an intermediate 1 that is separated and purified by column chromatography, (2) dissolving the intermediate 1 in methylene dichloride and adding 6-APA and an alkali to obtain ticarcillin, and (3) reacting ticarcillin with a salt forming agent to obtain ticarcillin disodium. |
| priorityDate |
2011-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |