| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_617110afb0c905c64fd0d4401e908bbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2227a3224d30936f73ba3f23a31d6789 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2012-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfe533481de5edd101126248886431b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab4b68976111720e9bc8d21689d879cd |
| publicationDate |
2012-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012178007-A1 |
| titleOfInvention |
COMPOSITIONS AND METHODS OF DIAGNOSING DISEASES AND DISORDERS ASSOCIATED WITH β CELL DEATH |
| abstract |
The present invention relates to compositions and methods for detecting cell death by detecting cell DNA in a biological sample. The invention relates the discovery that the presence of hypomethylated β cell DNA outside of the pancreas of a subject is indicative of β cell death. Thus, in one embodiment, the invention is a method of detecting hypomethylated β cell insulin DNA in a biological sample of a subject including the steps of: obtaining a biological sample from the subject, where the biological sample is obtained from outside of the subject's pancreas, and where the biological sample contains β cell insulin DNA; determining the methylation status of at least one of the CpG dinucleotides in the β cell insulin DNA, where when at least one of the CpG dinucleotides in the β cell insulin DNA is determined to be unmethylated, the hypomethylated β cell insulin DNA is detected. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3643795-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014138133-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015042288-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014164838-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3444361-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106574296-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015159293-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4026917-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9127317-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10508308-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106574296-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11203784-B2 |
| priorityDate |
2011-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |