http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012175031-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0eee9c68dd6351bac813fdcf0aaebb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61056434f1cf48853cdec3533a027ace http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1335967262b4f939cfaea13d4d30bf99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5df91b83742bcb8697bc96f405f4b8e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dd8ebef171af95f7d93e296298fb910 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 |
| filingDate | 2012-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1aff28496f16d931b0c8d0bc9743178d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61cb01ee359e0ce3c5d21467e2f62bd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6be057719dcfd35774f3d02edcc5883 |
| publicationDate | 2012-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2012175031-A1 |
| titleOfInvention | A process for the preparation of prasugrel and several novel crystalline forms of prasugrel hydrochloride |
| abstract | Disclosed are a process for the preparation of prasugrel and several novel crystalline forms of prasugrel hydrochloride. The process comprises preparation of prasugrel by acetylation in solvents which have low boiling point and /or low toxicity，and said process not only avoids using solvents which have high boiling point and /or high toxicity such as toluene, acetonitrile and so on, but also resolves the problem about thermal instability of prasugrel， and the lost of prasugrel is reduced， as well as the yield is raised. The yield of prasugrel is higher than 85％ and the purity is higher than 99.5%. The process can prepare the prasugrel and its pharmaceutically acceptable salts. The novel crystalline forms of prasugrel hydrochloride are crystalline form H1, H2 and H3, and their performance in oral absorbability, activate metabolism and activity in inhibiting platelet aggregation is excellent, and have a low toxicity and good thermal stability, applicable to the preparation of a drug for prevention or treatment of diseases caused by thrombosis or embolism. |
| priorityDate | 2011-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.