| abstract |
The present invention relates to a method for preparing a statin, and to certain compounds used as intermediates in this process. Preferably, the present invention relates to a method for preparing atorvastatin calcium, and to the following compounds: 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide, 1-[(R)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-hydroxy-5-oxo-hexyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrol-3-carboxamide, 1-((3R,5R)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,5-dihydroxyexyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrol-3-carboxamide and 5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1-((3R,7S)-3,5,7,8-tetrahydroxyoctyl)-1H-pyrrol-3-carboxamide, which are used as intermediates in the method. Moreover, the present invention relates to the method for preparing a statin, preferably atorvastatin calcium. The present invention further relates to the statins prepared by the method for preparing a statin, preferably atorvastatin calcium. |