Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f07ba5e7ff356b7eda43fdfc20eef4b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa5a331b4d3906bbee128126b00f0688 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-025 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
filingDate |
2012-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c83f255e5ffbee68879eb89354571dac |
publicationDate |
2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2012135857-A1 |
titleOfInvention |
Methods and compositions for treating brain diseases |
abstract |
The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner effective to infect an ependymal cell in the non-rodent mammal, wherein the ependymal cell secretes the therapeutic protein so as to treat the disease. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015013148-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105764532-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016540977-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2014293460-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160035596-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11103596-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016530246-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-245703-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2664471-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102423069-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017336395-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015013148-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10391184-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015077473-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3024497-A4 |
priorityDate |
2011-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |