| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3cd78093ffed22b5df6d88b8314d273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dadb1b70ceaefe844f878bffc9436d9d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2012-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68839fdddf57de9c8eb8286fbf131501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ab806d6a5aeadbdee3d35ce82a4c7a4 |
| publicationDate |
2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012135397-A2 |
| titleOfInvention |
Lactate-and ketones-induced gene signatures and use the same for diagnosing disease and predicting clinical outcome |
| abstract |
The present invention, at least in part, is directed to a method for discovering a biological marker (biomarker) of any cancer whose growth may be modulated by mitochondrial oxidative metabolism. In certain embodiments, the method comprises (a) contacting a set of at least one or more metabolites (e.g., 3-hydroxybutyrate or lactate or acetoacetate or oxaloacetate or citrate or a-ketoglutarate or glutamine or combinations thereof) to a first sample of a cancer cell line, a test cancer cell line; (b) assessing a level of gene expression pattern in the test cancer cell line; and (c) comparing the level of gene expression pattern of the test cancer cell line with a level of gene expression pattern in a second sample of the same cancer cell line not treated with the set of one or more metabolites, a control cancer cell line, whereby a difference between the level of the gene expression pattern in the test cancer cell line and the level of gene expression pattern in the control cancer cell line is a biomarker indicating mitochondrial oxidative metabolism in the cancer represented by the cancer cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023186985-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9797905-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016049286-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110050075-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110618271-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017041746-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108350507-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10539566-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110494570-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4253567-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11640849-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115637253-A |
| priorityDate |
2011-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |