| abstract |
The present invention relates generally to the fields of microbiology and biotechnology. More precisely, the present invention relates to novel paralog genes of hemiascomycetes yeast designated ECH1, ECH2, and ECH3 , which are addressed to the mitochondria, isolated nucleic acid molecules encoding the novel enoyl-CoA hydratase members and corresponding amino acid sequences thereof. The present invention also relates to isolated biologically pure hemiascomycetes yeast strains comprising unique combinations of metabolic pathways for the catabolism or degradation of fatty acid and other substrates. Finally, the present invention provides for novel mutants that can yield improved production of such commodity chemicals, as well as a method of increasing the production of commodity chemicals using the isolated biologically pure hemiascomycetes yeast strains. |