| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3551193727ece1612f9683bf12bd43a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21b9f25eaaf11a4d630fa95667de44cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_403b70615f9df720179958eadb4159dc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-52 |
| filingDate |
2012-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58b48fce023271be382a8cbaf0a70fe2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47e758d8032a342063a4465c9c1deb82 |
| publicationDate |
2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012125948-A1 |
| titleOfInvention |
Compositions and methods for producing clostridial collagenases |
| abstract |
The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium n histolyticum . The method utilizes an improved medium for the cultivation of Clostridium n histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10597632-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018160905-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020021330-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020021332-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020058755-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9725692-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020142701-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019169646-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013177647-A1 |
| priorityDate |
2011-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |