| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f31eb65a4801563ff5b4e45490ee20b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20a59bb48d0691a14fbf6296457a7521
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_432201d43043ba66fc9e19cbc850ce59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbf084d77f90d7b1599746a987a45349
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_529397c2e020925983485050e78da8d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82768d15207ca1bdd7b8e4d6ee4c393a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate |
2012-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b39f6f7d90e22f941417a06b580b9c25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_809759062714f70ef17ac995938fd055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6483fe0c6cc65cafc5745a04b522dfd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b6dd400de239b0fbc9a016c57597da9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0d56e37dbd069435972bccc55accafc |
| publicationDate |
2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012123966-A1 |
| titleOfInvention |
Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
| abstract |
4-Substituted-l,4-dihydropyridines of formula I are prepared by a cycloaddition reaction in which the cyclization is driven to completion at ambient temperature optionally in water without any catalyst. For exemplary purposes, the invention is described in particular detail with respect to the preparation of felodipine of formula II. Felodipine, a vasodilator, is prepared by a cycloaddition reaction of alkyl 3- aminocrotonate with dichlorobenzylidene under reaction conditions whereby the product crystallizes out of the reaction solution and may be directly isolated by filtration. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104177286-A |
| priorityDate |
2011-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |