| abstract |
A mutant GPCR which when compared to the corresponding parent receptor, has a different amino acid at a position which corresponds to any one or more of lie 10, Val 12, Trp 29, Ser 47, Ala 50, Phe 62, Thr 65, Ala 72, Ala 73, Phe 79, lie 80, Phe 83, Gin 89, Ala 97, Glu 212, Gin 214, Leu 216, Pro 217, Gly 218, Leu 225, Ala 236, lie 238, Phe 242, Phe 258, and Val 282 according to the numbering of the human adenosine A 2A receptor as set out in Figure 7 (SEQ ID No: 1). |