http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012115578-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91588ffa13b445e2b893c0e02dfa4518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c539db959cc0106cab1662303f94fce |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-173 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-173 |
filingDate | 2012-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d915e64b634dc1d081ec84c2c9da4e13 |
publicationDate | 2012-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | WO-2012115578-A1 |
titleOfInvention | Synthesis of flg |
abstract | The present invention concerns the synthesis of substantially anomerically pure 2,3-dideoxy-3- fluoro-5-0-(4-phenylbenzoyl)-a-D-erythropentofuranosyl chloride from an α/β-mixture of the corresponding methyl glycoside. The method of the invention provides the pure a-chloride without the need of anomeric separation. The α-chloride thus achieved is suitable for use as glycosyl donor in the preparation of 2',3'-dideoxy-3'-fluoro nucleosides. In particular, the preparation of 2',3'-dideoxy-3 '-fluoroguanosine, FLG, using an α/β-mixture of the methyl glycoside without the need of anomeric separation is disclosed. |
priorityDate | 2011-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 507.