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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_325ae95dc684543f96de7814ad8ea138
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publicationDate 2012-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2012110822-A1
titleOfInvention Method for identifying neonates at risk for necrotizing enterocolitis
abstract The invention provides a method for identifying a neonatal subject at risk for NEC, said method comprising (a) profiling the microbiota in a sample from the GI tract of said subject prior to a conclusive diagnosis of NEC and/or prior to full onset of NEC, (b1) comparing said profile to a standard microbiota profile obtained from corresponding samples from neonatal subjects with NEC or subjects which later developed NEC and determining the degree of correlation between said profile and the standard profile(s), and/or(b2) comparing said profile to a standard microbiota profile obtained from corresponding samples from neonatal subjects which did not develop NEC and determining the degree of correlation between said profile and the standard profile, and (c) identifying the subject as being at risk of NEC if significant correlation is observed in (b1) and/or significant correlation is not seen in (b2). An oligonucleotide probe set for use in the method of the invention, and kits containing the same, are also provided.
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