| abstract |
[Problem] To provide an excellent therapeutic or prophylactic agent for dementia, schizophrenia, and the like, which is based on a serotonin 5-HT 5A receptor-modulating action. [Solution] The present invention was realized by discovering that an isoquinoline derivative, wherein a ring group is bonded to position 1 of the isoquinoline ring and a ring group or the like is further bonded to position 7 of the isoquinoline ring via a linking group having an amide group, has a potent 5-HT 5A receptor-modulating action and an excellent pharmacological action based on that action, and by finding that the derivative is effective as a prophylactic or therapeutic agent for dementia, schizophrenia, and the like. |