| abstract |
The invention is directed to a method for reprogramming a fibroblast into a hiN, the method comprising expressing heterologous the reprogramming factors Brn2, Mytll, Zicl, 01ig2, Ascll or any combination thereof, and culturing said fibroblast in a medium comprising BDNF, NT3, GCM or any combination thereof. The invention also relates to hiN cells obtained according to the methods described herein. In another aspect, the invention relates to methods for screening compounds with the hiN cells described herein. |