| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9dc17ce337ef8d9ad1367d5456af56c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_826d6563befffdd0e1ff22b822f1b09b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_475912c1bb1804bb3b08c991b6eed661
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c929c99230ab8234d3271c2815cb3ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caae62975ebf0477f4f1a8010a5c68f1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-32 |
| filingDate |
2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95cd6865d23e1ef06e5a4fc42d101a9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34e0dd6a4ef711a470e1fbd6c5588e00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3c91a453958f88ad0497c7b66e68776
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c8696abbea6394016488d55d6d47500 |
| publicationDate |
2012-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012098563-A2 |
| titleOfInvention |
One-pot preparation of cyclobenzaprine hydrochloride |
| abstract |
Disclosed herein is a one-pot process for the preparation of pharmaceutically active cyclobenzaprine hydrochloride (Formula I) which comprises, reacting 5-dibenzosuberenone with Grignard reagent derived from 3-dimethylaminopropyl chloride. The reaction mass undergoes hydrolysis and dehydration reaction without isolation of intermediate compound in presence of aq. HCl solution. After completion of the reaction, the reaction mass is neutralized and the product is extracted in an organic solvent which is further converted to its hydrochloride salt. The method has the advantages of compact preparation process, low cost, high yield and suitability for large scale industrialized production. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102976955-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11517557-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019014651-A1 |
| priorityDate |
2011-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |