| abstract |
A compound having the structural formula (I) and pharmaceutically acceptable salt and/or hydrates thereof, (I) wherein Y is an arylester or an C 1 – C 8 alkylaryl ester, selected from the group consisting of: benzene, toluene, xylene, benzoic acid, benzoate, nicotinate, isonicotinate and halobenzene, which can be unsubstituted or substituted with at least one nitric oxide releasing group; and/or at least one of hydroxide, -Cl, -Br, a C 1 – C 8 alkyl, benzyl, a C 1 – C 8 alkoxy, benzyloxy, -NHC(O)R, -NH 2 , -NO 2, -ONO 2 , –(CH 2 ) n ONO 2 , –OC(O)[(CH 2 ) m ] cyclic ONO 2 , -OCOArONO 2 ,-OCOAr (CH 2 ) n ONO 2 or a C 1 – C 5 haloalkyl ester, wherein R is a C 1 – C 8 alkyl or a C 1 – C 8 alkoxy group, n=1-8 and m=3-10, to produce a super-aspirin effect. |