| abstract |
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein R is hydrogen or C 1 -6 alkyl,optionally substituted by one to five halogen atoms; n is 0,1,2 or 3; Ar is phenyl or a 5-or 6-membered heteroaromatic group containing 1,2 or 3 N atoms,which Ar is optionally substituted by one to three substituents selected from hal, hydroxyl,-CN,C 1-6 alkyl,C 2-3 alkenyl,C 2-3 alkynyl, C-6 alkoxy,C 3-6 cycloalkoxy and pyrazine,where C 1-6 alkyl and C 1-6 alkoxy are optionally substituted by one to three halogen atoms; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease1 caused by Aβ and typified by Alzheimer-type dementia. |