| abstract |
Novel benzothiazinone derivatives of formula (I) or a pharmaceutically acceptable salt or solvate thereof have been found to be effective against Mycobacterium tuberculosis strains and may thus be useful in the treatment of tuberculosis (I) wherein, EWG (electron withdrawing group) = N0 2 , CN, CF 3 , F, CI, Br, OCF 3 , OH, OR, OCHF 2 , COOR, wherein R is hydrogen, or a straight or branched C 1 -C 4 alkyl group, X = a bond, or a straight or branched C 1 -C 4 alkylene group; Y = a bond, or a straight or branched C 1 -C 4 alkylene group; wherein either one of X or Y is a bond and the other is a Ci-C4-alkylene group, Z = N or C, n = 1 or 2; R 1 = hydrogen, a straight or branched C 1 -C 6 alkyl group, or a C 3 -C 6 cycloalkyl group, which may be substituted with a group selected from F, CI, Br, I or a C 1 -C 4 alkoxy; R 2 = a phenyl group, a naphthyl group or a thienyl group, each of which may be unsubstituted or substituted with one or more substituent(s) which may be the same or different from each other, selected from the group consisting of F, CI, Br, I, CN, NO 2 , or a straight or branched C 1 -C 6 alkyl or phenyl group, which may be substituted with a group selected from F, CI, Br, I, or C 1 -C 4 alkoxy. |