| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0802691546ac04d5e3653d8a97efc818
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b58a94386dcbdc1833e05d422ddf207
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_577821cf81fda3e1088e6ed08bcd136b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-30 |
| filingDate |
2011-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7c8e4073e2c0d662f1616b637f6e500
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2307be7b4a9dbf11b12af2af462d81b9 |
| publicationDate |
2012-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012084895-A2 |
| titleOfInvention |
Crystal structure of flt3 ligand-receptor complex |
| abstract |
The present invention relates to the crystal structure of Flt3 and its cognate ligand FL. In particular, the binding interface of Flt3 and its cognate ligand FL has been determined. The present invention also relates to the applicability in modulating Flt3 activity. Methods for the identification as well as the rational design of mediators of Flt3 signaling are disclosed. In an aspect the method comprises a step of employing the atomic coordinates representing the three-dimensional structure of Flt3 and/or FL. In another aspect, the method comprises a step of contacting a candidate ligand with an Flt3 polypeptide comprising the FL binding site or alternatively an FL polypeptide comprising the Flt3 binding site, after which binding is determined |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104288765-A |
| priorityDate |
2010-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |