| abstract |
The present invention relates to a novel process for the preparation of pure Ebastine and use of the same in formulation without micronising. The invention further relates to the process of preparation of 1 -[4-(1, 1 -dimethyl ethyl) phenyl] -4-(4-hydroxy piperidin-1-yl) butan-1-one (compound II), an intermediate or preparation of Ebastine and use of the same in the preparation of pure Ebastine with the maximum particle size more than 1000 μm and D90 from 250 μm -1000 μm. |