| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48635c751258c12eaa300cd853e20dc3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea57544421e14ebd0765bd9516e5c43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4572a6943c8d83a294530e4f9787f7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_057aa87bbd10d372171d6947d57d948a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_944fb57115732c5d0f48be98513f4cf8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4458
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4462
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4462
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4458
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate |
2011-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3255e45cdcf72f0386dbb9328cc9042a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71dda45411f8585f0436dc591a260e70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e21999c4be57cc5009173975add542b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95b1f5cfbdbd93933b447696c3f0e410 |
| publicationDate |
2012-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012076667-A1 |
| titleOfInvention |
Compounds for treatment of heart failure |
| abstract |
A combination of: a first tetracycline (TC) component; and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO effects in vivo (NO mimetic). The combinations of the invention advantageously act as more effective MMP modulators with selective reductions in circulating MMP-9 levels in-vivo and inhibitory effects on MMP-2 and MMP-9 levels in-vitro. The combinations of the invention also advantageously act as modulators of inflammation mediators. The co-existence of abnormalities of MMP enzymes and inflammation in many diseases make these characteristics advantageous. Therefore, the various combinations of the invention find utility in medical applications where MMPs and/or inflammation is implicated. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105101977-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016510040-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2961479-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016507570-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2953631-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11219640-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102976965-A |
| priorityDate |
2010-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |