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publicationDate 2012-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2012075138-A1
titleOfInvention Method of producing biologically active vitamin k dependent proteins in transgenic animals
abstract A method is disclosed of increasing the biological activity of a Vitamin K dependent protein produced in a transgenic animal, cell or cell line comprising feeding a transgenic animal or cell /cell line expressing a gene encoding the Vitamin K dependent protein an animal feed or media comprising an increased amount of vitamin K over that of standard animal feed containing a standard amount of vitamin K. The Vitamin K dependent protein expressed in the transgenic animal possesses an increased biological activity over a Vitamin K dependent protein expressed in a transgenic animal that is fed standard animal feed or standard media containing a standard amount of Vitamin K where the biological activity is increased as a result of an increase of gamma carboxylation of the Vitamin K dependent protein.
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