| abstract |
Provided is a novel therapeutic agent for myeloma. A pyrazole compound represented by general formula (1) (In the formula: R 1 represents a C1-6 alkyl, an R 17 -substituted C1-6 alkyl, a C1-6 haloalkyl, a phenyl, or a phenyl substituted by a number (a) of R 11 , or the like; R 2 represents a hydrogen atom, a C1-6 alkyl, a phenyl, or a phenyl optionally substituted by a number (e) of R 21 , or the like; R 3 represents a hydrogen atom or the like; x represents a single bond or -(CR 6 R 7 ) n -; R 4 and R 5 each independently represent a C1-6 alkyl or the like; R 6 and R 7 represent a hydrogen atom or a C1-6 alkyl; and R 8 represents a phenyl, or a phenyl optionally substituted by a number (k) of R 81 , or the like.), a tautomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a therapeutic agent for multiple myeloma containing the aforementioned as an active ingredient. |