Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b16bb68a809ced2262eaa7758b1d58e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b9bf983681da443f0e1b2336f26f630 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59a64c96b008aa6505548acb3cc0fa68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb1145753f015de2f4f0bcc1554a72e7 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-766 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-366 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-766 |
filingDate |
2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e1c204ff0de9bddaa1e20751bbce85b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a724c15cd5acce1bd77fab2f10e26004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94e9a92a310c82bbe39b1f4407b474a1 |
publicationDate |
2013-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2012071453-A8 |
titleOfInvention |
Modulating oncolytic vsv and upregulating rae1 and nup98 with statins |
abstract |
Simvastatin is used to modulate VSV infection at the level of viral replication. Both lipid-lowering and pleiotropic cellular effects of simvastatin are exploited in the modulation. Simvastatin upregulates the expression of Rael and Nup98, therefore altering normal cellular mRNA distribution and reverting VSV's mRNA export block. Furthermore, simvastatin causes redistribution of Flotillin-1, which affects VSV replication/budding. Simvastatin is further used as a neoadjuvant for the selective modulatory control of live VSV oncolytic therapy. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109985242-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109985242-B |
priorityDate |
2010-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |