| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7f015c7c3b1e8b919f0fa7e816e4ed1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e021d0c6852d6882424479b78f14879
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5a41871a39a95e0d3148135c71947ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10045ff5d203204a9248a2d2d8885e94 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2835 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-02019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 |
| filingDate |
2011-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e5c7422b7d867c6540b4c09dafe164e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7872288eb2ddeeb2a3687012bd454408
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d565ef07adfb94a047dbdecf77350d9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_236e29e76c7913dd2ae998a0997ffc71 |
| publicationDate |
2012-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012067970-A2 |
| titleOfInvention |
Transcriptional repression leading to parkinson's disease |
| abstract |
Parkinson's disease is caused by the preferential loss of substantia nigra dopamine neurons. A Parkin Interacting Substrate, PARIS (ZNF746) is identified. The levels of PARIS are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human brain Parkinson's disease patients. PARIS represses the expression of the transcriptional co-activator, PGC-1α and the PGC-lα target gene, NRF-1 by binding to insulin response sequences in the PGC-lα promoter. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine (DA) neurons that is PARIS dependent. Overexpression of PARIS causes selective loss of DA neurons in the substantia nigra, which is reversed by either parkin or PGC-lα co-expression. The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3429569-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107107475-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3810781-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019002655-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107107475-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107419008-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107419008-B |
| priorityDate |
2010-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |