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filingDate 2011-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2012061105-A2
titleOfInvention Homozygous and heterozygous idh1 gene-defective cell lines derived from human colorectal cells
abstract IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous) have been made from a robust cell line, HCT116. The IDH1 gene-defective cell lines can be used to determine the effect of IDH1R132H on cell biology, tumorigenesis, and cellular metabolic profiles. These cell lines can be used to test potential therapeutic targets and to screen potential therapeutic agents. Kits and xenografts are also contemplated.
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