| abstract |
The present patent application relates to indolobenzazepine derivatives having an antitumor activity, to the synthesis thereof, and to the use thereof. In particular, the present patent application relates to the stereocontrolled synthesis of C5-substituted indolobenzazepinones enabling only one of the two possible C5 isomers to be obtained, as well as water-soluble analogs making it possible to demonstrate the very high effectiveness of said molecules in reducing the size of tumors in vivo . |