| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2692880e5aa7949041189be428dadd31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90c8d940d45b673db2afe075135e2be5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69086f9f1ca752b12f468ee09dd88375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_425d09eec198a684ce90c3f6f20868ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f54f0b5d64d41ebaeb2f1f2dca65ff7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30488690e6414f4f2fa7fc09596d6d66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2effa7afdc95cf341ad587762458727d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6845
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-087 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04 |
| filingDate |
2011-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_083b7fef98cc8aa53ff1eb693fa47cc3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc8ef9045d933c21eaf893cc94c55ec3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38985bd21226edf9646a31da412a14ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36537155314f995a65c7c35d57fa7042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6470269c2077e8e285e80b5724be3f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_960700540a372fe89b276322a1b7020e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_687865c45b89f364b17da4195b0dabe7 |
| publicationDate |
2012-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012058137-A2 |
| titleOfInvention |
Methods for diversifying antibodies, antibodies derived therefrom and uses thereof |
| abstract |
The invention provides methods of introducing diversity into antibody molecules comprising introducing or substituting at least one amino acid sequence in the CDR of the target antibody together with at least one amino acid in the FW region spanning the 3 amino acid adjoining the CRD on each side. The resulting diverse antibodies with variant CDRs and FW region sequences comprising diverse amino acid sequences are also described. These polypeptides regions, herein referred to as 3+CDR3+, that form the gist of the invention contribution described herein provide a flexible and simple source of sequence diversity that can be used as a source for expressing and identifying diverse antibodies or antigen binding polypeptides. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided. A method of producing diverse antibodies comprising amino acid substitutions in one of the CDR region and the FW region comprising 3 contiguous FW sequence amino acids adjacent to each CDR on either side is described herein. The substitutions are relative to database or germline sequences. Not all substitution are preserved in conservative regions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9433687-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793643-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017024146-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11421037-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10669343-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017118307-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10786578-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113406592-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3741852-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016020791-A1 |
| priorityDate |
2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |